HCID 22008807, compound → HCID 22008839, compound

Participants

Reaction Steps

Butyl lithium (3.1 ml, 0.9 M in hexanes, 2.8 mmol) was added dropwise to a solution of 1-(2-bromo-5-methoxybenzoyl)-2,3dihydro-4-pyridinone (0.75 g, 2.4 mmol) in THF (20 ml) at −78° C. After stirring for 2 h, the reaction was quenched with water, extracted with ethyl acetate, the extract dried over magnesium sulphate and evaporated. The residue was purified by flash column chromatography on silica eluting with 50% ethyl acetate in hexane to yield the title compound as a colourless oil (240 mg). MS (+EI) m/z 231 [M+].

Provenance & Evidence