HRID322041

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(CC(=O)N[C@@H]1CCc2c(ccc3ccccc23)NC1=O)NC(=O)OCc1ccccc1

HCID20641421

未命名化合物

结构：CC(C)(C)OC(=O)NCc1ccccc1-c1ccc(CO)cc1

HCID22008472

未命名化合物

PRODUCTS

生成物

结构：CC(C)(CC(=O)N[C@@H]1CCc2c(ccc3ccccc23)N(Cc2ccc(-c3ccccc3CNC(=O)OC(C)(C)C)cc2)C1=O)NC(=O)OCc1ccccc1

HCID20641423

未命名化合物

PROCEDURE

实验过程

The product of Step B is prepared from 3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-4-oxo-1H-naphtho[2,1-b]azepin-3(R)-yl]butanamide (Step A) and 2′-[(t-butoxycarbonylamino)methyl]-1,1′-biphenyl-4-methanol, methanesulfonate ester (Example 1, Step G) according to the procedure for Example 1, Step H.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-42dc8f2981ef4db187b6a59d56bd0aa6
来源数据集: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06211174B1
来源说明: uspto-grants-2001_04

反应 SMILES

[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:34])([CH3:33])[CH2:13][C:14]([NH:16][C@H:17]1[C:23](=[O:24])[NH:22][C:21]2[CH:25]=[CH:26][C:27]3[C:32]([C:20]=2[CH2:19][CH2:18]1)=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:35]([O:39][C:40]([NH:42][CH2:43][C:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[C:50]1[CH:55]=[CH:54][C:53]([CH2:56]O)=[CH:52][CH:51]=1)=[O:41])([CH3:38])([CH3:37])[CH3:36]>>[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:34])([CH3:33])[CH2:13][C:14]([NH:16][C@H:17]1[C:23](=[O:24])[N:22]([CH2:56][C:53]2[CH:52]=[CH:51][C:50]([C:45]3[CH:46]=[CH:47][CH:48]=[CH:49][C:44]=3[CH2:43][NH:42][C:40]([O:39][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:41])=[CH:55][CH:54]=2)[C:21]2[CH:25]=[CH:26][C:27]3[C:32]([C:20]=2[CH2:19][CH2:18]1)=[CH:31][CH:30]=[CH:29][CH:28]=3)=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1