Methyl morpholine oxide → Methyl 2-chloro-3-formyl-4-methylsulfonylbenzoate

Participants

Reaction Steps

89.2 g (0.26 mol) of methyl 2-chloro-3-bromomethyl-4-methylsulfonylbenzoate are dissolved in 500 ml of acetonitrile and treated at room temperature with 52.0 g (0.444 mol) of N-methylmorpholine N-oxide. The batch is stirred at room temperature for 18 hours, concentrated in a rotary evaporator, taken up in dichloromethane and washed several times with water. After concentration in the rotary evaporator, 57.3 g (80% of theory) of methyl 2-chloro-3-formyl-4-methylsulfonylbenzoate having a melting point of 104-105° C. are obtained.

Provenance & Evidence