HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Proline → HCID 69711854, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| Reactant | HCID 69710318 | HCID 69710318 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 69711854 | HCID 69711854 | — |
Reaction Steps
A mixture of 2-7 (450 mg, 1.2 mmol), 2-amino-3-formylpyridine (145 mg, 1.2 mmol; for prep., see JOC 1983,48, 3401) and proline (137 mg, 1.2 mmol) in absolute ethanol (20 mL) was heated at reflux for 12 h. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 50% ethyl acetate/chloroform to 70:25:5 chloroform/ethyl acetate/MeOH) to give 2-8 as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211191B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-687c72be89674a79964a4dd26aaa18e0 |
| Source note | uspto-grants-2001_04 |