反应详情

The solution of 3-benzyloxycarbonyl-5-(2-cyanoethoxy)carbonyl-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)pyridine (3.24 g, 7.02 mmol) in 160 ml of 4.4% (w/w) formic acid/MeOH mixture was stirred with Pd/C (10%, 3.24 g) for 30 min., the reaction was quenched by addition of 10 ml of CHCl3. The mixture was filtered and concentration of filtrate give a yellow powder, which was dissolved in CHCl3, washed with water and 1N HCL. After drying and removal of solvent, 3-(2-cyanoethoxy)carbonyl-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)pyridine-5- carboxylic acid was obtained as a yellow powder (1.94 g, 75%)

1. customthe reaction was quenched by addition of 10 ml of CHCl3
2. filtrationThe mixture was filtered
3. customconcentration of filtrate give a yellow powder, which
4. washwashed with water and 1N HCL
5. customAfter drying
6. customremoval of solvent