(2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acid → HCID 29939081, compound

HRID 322234Notes

Reaction equation

HRID 322234 reaction equation
[NH2:1][C:2]1[C:7]2[C:8](=[O:16])[C:9]3[S:15][CH:14]=[CH:13][C:10]=3[CH2:11][S:12][C:6]=2[CH:5]=[CH:4][CH:3]=1.[F:17][C:18]([F:26])([F:25])[C@:19]([OH:24])([CH3:23])[C:20](O)=[O:21]>>[F:17][C:18]([F:26])([F:25])[C@:19]([OH:24])([CH3:23])[C:20]([NH:1][C:2]1[C:7]2[C:8](=[O:16])[C:9]3[S:15][CH:14]=[CH:13][C:10]=3[CH2:11][S:12][C:6]=2[CH:5]=[CH:4][CH:3]=1)=[O:21]

Participants

3

Reactant 2

HCID 7019028(2S)-3,3,3-Trifluoro-2-hydroxy-2-methylpropanoic acidHCID 15524296HCID 15524296, compound

Product 1

HCID 29939081HCID 29939081, compoundYield 99%

Procedure

Substantially the same procedure as in Reference Example 7 was repeated using 9-amino-4,10-dihydrothieno[3,2-c][1]benzothiepin-10-one obtained in Reference Example 5 (0.56 g, 2.26 mmol) and (S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid obtained in Reference Example 12 (0.72 g, 4.52 mmol) to give (S)-9-(3,3,3-trifluoro-2-hydroxy-2-methylpropanoylamino)-4,10-dihydrothieno[3,2-c][1]benzothiepin-10-one (0.87 g, 99%).

Sources & evidence

ORD record
ord-f72ab2e27e9746b49c59febe3b099353
Source dataset
uspto-grants-2001_04
Patent number
US06211227B1

Reaction notes

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