反应详情

Substantially the same procedure as in Reference Example 7 was repeated using 9-amino-4,10-dihydrothieno[3,2-c][1]benzothiepin-10-one obtained in Reference Example 5 (0.56 g, 2.26 mmol) and (S)-3,3,3-trifluoro-2-hydroxy-2-methylpropanoic acid obtained in Reference Example 12 (0.72 g, 4.52 mmol) to give (S)-9-(3,3,3-trifluoro-2-hydroxy-2-methylpropanoylamino)-4,10-dihydrothieno[3,2-c][1]benzothiepin-10-one (0.87 g, 99%).