Sodium Hydroxide → 2-(3-Methoxyphenylthiomethyl)-6-nitrobenzoic acid

Participants

Reaction Steps

In methanol (10 ml) was dissolved methyl 2-(3-methoxyphenylthiomethyl)-6-nitrobenzoate obtained in Reference Example 16 (0.96 g, 2.88 mmol), and a 4 mol/l aqueous solution of sodium hydroxide (10 ml) was added thereto, followed by heating under reflux for 2 hours. After the reaction, the reaction mixture was concentrated and adjusted to pH 3 with a 1 mol/l aqueous solution of hydrochloric acid to give 2-(3-methoxyphenylthiomethyl)-6-nitrobenzoic acid as a precipitated white solid (0.85 g, 92%).

Provenance & Evidence