Methanesulfonyl chloride → HCID 22009798, compound

HRID 322243Notes

Reaction equation

[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][OH:27])=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:28][S:29](Cl)(=[O:31])=[O:30]>>[CH3:28][S:29]([O:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][C:19]1[CH:18]=[CH:17][C:16]([O:15][CH2:14][C:12]2[N:13]=[C:9](/[CH:8]=[CH:7]/[C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[O:10][CH:11]=2)=[CH:21][CH:20]=1)(=[O:31])=[O:30]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 22009699HCID 22009699, compound

Product 1

HCID 22009798HCID 22009798, compoundYield 96%

Procedure

In substantially the same manner as in Reference Example 12, 5-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]pentanol was allowed to react with methanesulfonyl chloride to give 5-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]pentyl methanesulfonate. The yield was 96%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 105-106° C.

Sources & evidence

ORD record: ord-16c87359c376462f93c6f31440110164
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Reaction notes

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