Methanesulfonyl chloride → HCID 22009766, compound

HRID 322246Notes

Reaction equation

[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:22][CH2:23][CH2:24][OH:25])[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[CH3:26][S:27]([O:25][CH2:24][CH2:23][CH2:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][CH2:14][C:12]1[N:13]=[C:9](/[CH:8]=[CH:7]/[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[O:10][CH:11]=1)(=[O:29])=[O:28]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 22009678HCID 22009678, compound

Product 1

HCID 22009766HCID 22009766, compoundYield 95%

Procedure

In substantially the same manner as in Reference Example 12, 3-[2-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propanol was allowed to react with methanesulfonyl chloride to give 3-[2-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate. The yield was 95%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 93-94° C.

Sources & evidence

ORD record: ord-f870607aba514d2288abd3655bd714ee
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Reaction notes

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