1H-1,2,4-Triazole → HCID 54462295, compound

HRID 322254Notes

Reaction equation

HRID 322254 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][CH2:17]O)=[CH:11][C:10]=1[O:19][CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:21]1[CH:25]=[N:24][CH:23]=[N:22]1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:16][CH2:17][N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)=[CH:11][C:10]=1[O:19][CH3:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 54535409HCID 54535409, compound

Product 1

HCID 54462295HCID 54462295, compoundYield 34%

Procedure

In substantially the same manner as in Reference Example 25, 3-(4-benzyloxy-3-methoxyphenyl)-2-propen-1-ol was allowed to react with 1,2,4-triazole to give 1-[3-(4-benzyloxy-3-methoxyphenyl)-2-propenyl]-1,2,4-triazole. The yield was 34%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 70-72° C.

Sources & evidence

ORD record
ord-d528b95d414b49ceb21cd66ae7d429e7
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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