反应详情

A mixture of 1-[4-(4-benzyloxyphenyl)butyl]-1,2,4-triazole (3.15 g), palladium-carbon (5%, 3.0 g) and ethanol (50 ml) was subjected to catalytic hydrogenation under atmospheric pressure at room temperature. The catalyst was filtered off, and the filtrate was concentrated. The residue was subjected to a silica gel column chromatography. The crystalline product obtained from the fraction eluted with tetrahydrofuran-hexane (1:1, v/v) was recrystallized from ethyl acetate-hexane to give 1-[4-(4-hydroxyphenyl)butyl]-1,2,4-triazole (1.22 g, 55%) as colorless prisms, mp 135-136° C.

1. customwas subjected to catalytic hydrogenation under atmospheric pressure at room temperature
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate was concentrated
4. customThe crystalline product obtained from the fraction
5. washeluted with tetrahydrofuran-hexane (1:1
6. customv/v) was recrystallized from ethyl acetate-hexane