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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322258Generated: October 29, 2026

1,3-Dichloroacetone → 4-(Chloromethyl)-2-(3,4-dihydronaphthalen-2-yl)oxazole

https://huagongshe.com/reaction/322258

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DichloroacetoneHCID 10793—
Reactant3,4-Dihydro-2-naphthalenecarboxamideHCID 22009819—
Product4-(Chloromethyl)-2-(3,4-dihydronaphthalen-2-yl)oxazoleHCID 2200963760%

Reaction Steps

In substantially the same manner as in Reference Example 31, 3,4-dihydro-2-naphthalenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3,4-dihydro-2-naphthyl)oxazole. The yield was 60%. Recrystallization from isopropyl ether gave colorless prisms, mp 73-74° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-925a11c0d6e349ac82ecc515deccfd8e
Source noteuspto-grants-2001_04