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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322260Generated: October 25, 2026

1,3-Dichloroacetone → 4-(Chloromethyl)-2-(propan-2-yl)-1,3-oxazole

https://huagongshe.com/reaction/322260

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DichloroacetoneHCID 10793—
ReactantIsobutyramideHCID 68424—
Product4-(Chloromethyl)-2-(propan-2-yl)-1,3-oxazoleHCID 27632916.2%

Reaction Steps

In substantially the same manner as in Reference Example 31, isobutyramide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-isopropyl oxazole as an oily product. The yield was 6.2%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-08f66c51c9c04a2db715dc2ff5cdaa9f
Source noteuspto-grants-2001_04