1,3-Dichloroacetone → HCID 22009622, compound

HRID 322263Notes

Reaction equation

HRID 322263 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([NH2:14])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:18][CH2:19][C:20]([CH2:22]Cl)=O>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:12]2[O:13][CH:22]=[C:20]([CH2:19][Cl:18])[N:14]=2)[CH:15]=[CH:16][CH:17]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 6461349HCID 6461349, compound

Product 1

HCID 22009622HCID 22009622, compoundYield 26%

Procedure

In substantially the same manner as in Reference Example 31, 3-benzyloxybenzamide was allowed to react with 1,3-dichloroacetone to give 2-(3-benzyloxyphenyl)-4-chloromethyloxazole. The yield was 26%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 49-50° C.

Sources & evidence

ORD record
ord-0259e3015af04f2ba9c7d00e14695ae4
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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