Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322265Generated: October 25, 2026

1,3-Dichloroacetone → 4-Chloromethyl-2-(3,5-dimethylphenyl)oxazole

https://huagongshe.com/reaction/322265

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DichloroacetoneHCID 10793—
Reactant3,5-DimethylbenzamideHCID 319485—
Product4-Chloromethyl-2-(3,5-dimethylphenyl)oxazoleHCID 2200962852%

Reaction Steps

In substantially the same manner as in Reference Example 31, 3,5-dimethylbenzamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3,5-dimethylphenyl)oxazole. The yield was 52%. Recrystallization from isopropyl ether gave colorless needles, mp 76-77° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-3ab89e7985c0403891800f8cfb004588
Source noteuspto-grants-2001_04