HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloroacetone → 4-[4-(Chloromethyl)-1,3-oxazol-2-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloroacetone | HCID 10793 | — |
| Reactant | p-Cyanobenzamide | HCID 76427 | — |
| Product | 4-[4-(Chloromethyl)-1,3-oxazol-2-yl]benzonitrile | HCID 22009640 | 41% |
Reaction Steps
In substantially the same manner as in Reference Example 31, 4-cyanobenzamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(4-cyanophenyl)oxazole. The yield was 41%. Recrystallization form ethyl acetate-hexane gave colorless prisms, mp 134-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-8f68c7735093494694dce59073b3aa24 |
| Source note | uspto-grants-2001_04 |