1,3-Dichloroacetone → HCID 10977667, compound

HRID 322269Notes

Reaction equation

HRID 322269 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]([NH2:13])=[O:12].[Cl:14][CH2:15][C:16]([CH2:18]Cl)=O>>[Cl:14][CH2:15][C:16]1[N:13]=[C:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)[O:12][CH:18]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 75245Naphthalene-2-carboxamide

Product 1

HCID 10977667HCID 10977667, compoundYield 68%

Procedure

In substantially the same manner as in Reference Example 31, 2-naphthalenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(2-naphthyl)oxazole. The yield was 68%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 116-117° C.

Sources & evidence

ORD record
ord-30e6e39eca5b45dfa7e9445a00267936
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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