1,3-Dichloroacetone → HCID 22009858, compound

HRID 322270Notes

Reaction equation

HRID 322270 reaction equation
[S:1]1[C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[Cl:13][CH2:14][C:15]([CH2:17]Cl)=O>>[S:1]1[C:5]([C:6]2[O:7][CH:17]=[C:15]([CH2:14][Cl:13])[N:8]=2)=[CH:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 2370731-Benzothiophene-2-carboxamide

Product 1

HCID 22009858HCID 22009858, compoundYield 33%

Procedure

In substantially the same manner as in Reference Example 31, 2-benzo[b]thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 2-(2-benzo[b]thienyl)-4-chloromethyloxazole. The yield was 33%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 150-151° C.

Sources & evidence

ORD record
ord-434f824289734849b49c1aafb76c565d
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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