1,3-Dichloroacetone → 4-Chloromethyl-2-(1-propenyl)oxazole

HRID 322274Notes

Reaction equation

[C:1]([NH2:6])(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[Cl:7][CH2:8][C:9]([CH2:11]Cl)=O>>[Cl:7][CH2:8][C:9]1[N:6]=[C:1]([CH:2]=[CH:3][CH3:4])[O:5][CH:11]=1

Participants

Reactant 2

HCID 107931,3-Dichloroacetone

HCID 53544872-Butenamide

Product 1

HCID 540924474-Chloromethyl-2-(1-propenyl)oxazoleYield 10%

Procedure

In substantially the same manner as in Reference Example 47, crotonamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(1-propenyl)oxazole. The yield is 10%. Oily substance.

Sources & evidence

ORD record: ord-c5e92be0e99b4eaebca75dcb70548e75
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Reaction notes

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