HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Dichloroacetone → 4-Chloromethyl-2-(5-methyl-2-thienyl)oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Dichloroacetone | HCID 10793 | — |
| Reactant | 5-Methyl-2-thiophenecarboxamide | HCID 580730 | — |
| Product | 4-Chloromethyl-2-(5-methyl-2-thienyl)oxazole | HCID 22241454 | 46% |
Reaction Steps
In substantially the same manner as in Reference Example 47, 5-methyl-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(5-methyl-2-thienyl)oxazole. The yield was 46%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 84-85° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-2de3de7cd7b643959d60c084db8aca33 |
| Source note | uspto-grants-2001_04 |