1,3-Dichloroacetone → HCID 22009653, compound

HRID 322281Notes

Reaction equation

HRID 322281 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([NH2:8])=[O:7])=[CH:2]1.[Cl:9][CH2:10][C:11]([CH2:13]Cl)=O>>[Cl:9][CH2:10][C:11]1[N:8]=[C:6]([C:3]2[CH:4]=[CH:5][S:1][CH:2]=2)[O:7][CH:13]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 11205757Thiophene-3-carboxamide

Product 1

HCID 22009653HCID 22009653, compoundYield 50%

Procedure

In substantially the same manner as in Reference Example 47, 3-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3-thienyl)oxazole. The yield was 50%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 91-92° C.

Sources & evidence

ORD record
ord-a36b77de2d3747f68a8780ad3cb4fc22
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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