1,3-Dichloroacetone → HCID 22009717, compound

HRID 322285Notes

Reaction equation

HRID 322285 reaction equation
[CH2:1]([C:3]1[S:7][C:6]([C:8]([NH2:10])=[O:9])=[CH:5][CH:4]=1)[CH3:2].[Cl:11][CH2:12][C:13]([CH2:15]Cl)=O>>[Cl:11][CH2:12][C:13]1[N:10]=[C:8]([C:6]2[S:7][C:3]([CH2:1][CH3:2])=[CH:4][CH:5]=2)[O:9][CH:15]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 12836068HCID 12836068, compound

Product 1

HCID 22009717HCID 22009717, compoundYield 54%

Procedure

In substantially the same manner as in Reference Example 47, 5-ethyl-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(5-ethyl-2-thienyl)oxazole. The yield was 54%.

Sources & evidence

ORD record
ord-4f150a771651483ebf0673bf46c0044f
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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