1,3-Dichloroacetone → HCID 22009666, compound

HRID 322290Notes

Reaction equation

HRID 322290 reaction equation
[CH3:1][C:2]1[O:6][C:5]([C:7]([NH2:9])=[O:8])=[CH:4][CH:3]=1.[Cl:10][CH2:11][C:12]([CH2:14]Cl)=O>>[Cl:10][CH2:11][C:12]1[N:9]=[C:7]([C:5]2[O:6][C:2]([CH3:1])=[CH:3][CH:4]=2)[O:8][CH:14]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 51663345-methylfuran-2-carboxamide

Product 1

HCID 22009666HCID 22009666, compoundYield 38%

Procedure

In substantially the same manner as in Reference Example 47, 5-methyl-2-furancarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(5-methyl-2-furyl)oxazole. The yield was 38%. Recrystallization from diethyl ether-hexane gave. Colorless needles, mp 93-94° C.

Sources & evidence

ORD record
ord-08b185176c444fa3876f04ffd4f2f022
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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