1,3-Dichloroacetone → HCID 22009623, compound

HRID 322292Notes

Reaction equation

HRID 322292 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:7]([NH2:9])=[O:8])[S:5][CH:6]=1.[Cl:10][CH2:11][C:12]([CH2:14]Cl)=O>>[Cl:10][CH2:11][C:12]1[N:9]=[C:7]([C:4]2[S:5][CH:6]=[C:2]([Cl:1])[CH:3]=2)[O:8][CH:14]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 22716499HCID 22716499, compound

Product 1

HCID 22009623HCID 22009623, compoundYield 48%

Procedure

In substantially the same manner as in Reference Example 47, 4-chloro-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(4-chloro-2-thienyl)oxazole. The yield was 48%. Recrystallization from diethyl ether-hexane gave colorless needles, mp 72-73° C.

Sources & evidence

ORD record
ord-3f8411a85f08443b996bec10198c03f3
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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