1,3-Dichloroacetone → HCID 22009802, compound

HRID 322293Notes

Reaction equation

HRID 322293 reaction equation
[CH3:1][O:2][C:3]1[S:7][C:6]([C:8]([NH2:10])=[O:9])=[CH:5][CH:4]=1.[Cl:11][CH2:12][C:13]([CH2:15]Cl)=O>>[Cl:11][CH2:12][C:13]1[N:10]=[C:8]([C:6]2[S:7][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[O:9][CH:15]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 593880HCID 593880, compound

Product 1

HCID 22009802HCID 22009802, compoundYield 1.2%

Procedure

In substantially the same manner as in Reference Example 47, 5-methoxy-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(5-methoxy-2-thienyl)oxazole. The yield was 1.2%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 64-65° C.

Sources & evidence

ORD record
ord-8a1881c581e4486eaae0e49045d7c9a4
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

Loading…