HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(thiophen-2-yl)-1,3-thiazole-4-carboxylate → [2-(2-Thienyl)-1,3-thiazol-4-YL]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(thiophen-2-yl)-1,3-thiazole-4-carboxylate | HCID 2743947 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Product | [2-(2-Thienyl)-1,3-thiazol-4-YL]methanol | HCID 2776319 | 94% |
Reaction Steps
In substantially the same manner as in Reference Example 72, ethyl 2-(2-thienyl)-4-thiazolecarboxylate was reduced with lithium aluminum hydride to give crystals of 2-(2-thienyl)-4-thiazolylmethanol. The yield was 94%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 54-55° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-828cd7e6feb54994961b97f096215830 |
| Source note | uspto-grants-2001_04 |