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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322298Generated: October 25, 2026

Thionyl Chloride → 4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-thiazole

https://huagongshe.com/reaction/322298

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant[2-(2-Thienyl)-1,3-thiazol-4-YL]methanolHCID 2776319—
Product4-(Chloromethyl)-2-(thiophen-2-yl)-1,3-thiazoleHCID 73649665%

Reaction Steps

In substantially the same manner as in Reference Example 73, 2-(2-thienyl)-4-thiazolylmethanol was allowed to react with thionylchloride to give 4-chloromethyl-2-(2-thienyl)thiazole. The yield was 65%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 54-55° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-5a7fb9cf4746443198935858846d7d80
Source noteuspto-grants-2001_04