Imidazole → 5-[3-(1-Imidazolyl)propyl]-2-methoxypyridine

HRID 322317Notes

Reaction equation

HRID 322317 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[N:13][CH:14]=1)(=O)=O.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>>[N:17]1([CH2:6][CH2:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[N:13][CH:14]=2)[CH:21]=[CH:20][N:19]=[CH:18]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 220098553-(2-Methoxy-5-pyridyl)propyl methanesulfonate

Product 1

HCID 220098285-[3-(1-Imidazolyl)propyl]-2-methoxypyridineYield 94%

Procedure

In substantially the same manner as in Reference Example 88, 3-(2-methoxy-5-pyridyl)propyl methanesulfonate was reacted with imidazole to give 5-[3-(1-imidazolyl)propyl]-2-methoxypyridine. The yield was 94%. Oily substance.

Sources & evidence

ORD record
ord-8cf39828ca28470dbd7712c81e05996f
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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