1,3-Dichloroacetone → HCID 22009783, compound

HRID 322319Notes

Reaction equation

HRID 322319 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([NH2:8])=[O:7])=[CH:2]1.[Cl:9][CH2:10][C:11]([CH2:13]Cl)=O>>[Cl:9][CH2:10][C:11]1[N:8]=[C:6]([C:3]2[CH:4]=[CH:5][O:1][CH:2]=2)[O:7][CH:13]=1

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 17914258Furan-3-carboxamide

Product 1

HCID 22009783HCID 22009783, compoundYield 44%

Procedure

In substantially the same manner as in Reference Example 47, 3-furancarboxamide was reacted with 1,3-dichloroacetone to give 4-chloromethyl-2-(3-furyl)oxazole. The yield was 44%. Recrystallization from diethyl ether-hexane gave colorless prisms. mp 70-71° C.

Sources & evidence

ORD record
ord-5f80dca0704e405ea815d21d1a7df769
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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