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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322320Generated: October 26, 2026

1,3-Dichloroacetone → 4-Chloromethyl-2-(2-thienylmethyl)oxazole

https://huagongshe.com/reaction/322320

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DichloroacetoneHCID 10793—
ReactantThiophen-2-acetamideHCID 78208—
Product4-Chloromethyl-2-(2-thienylmethyl)oxazoleHCID 2200960827%

Reaction Steps

In substantially the same manner as in Reference Example 47, 2-thiopheneacetamide was reacted with 1,3-dichloroacetone to give 4-chloromethyl-2-(2-thienylmethyl)oxazole. The yield was 27%. Oily substance.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-e576de2d248e4d1ab3eaf0e7d641e0ad
Source noteuspto-grants-2001_04