Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322323Generated: October 31, 2026

1,3-Dichloroacetone → 4-Chloromethyl-2-(5-cyano-2-thienyl)oxazole

https://huagongshe.com/reaction/322323

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-DichloroacetoneHCID 10793—
Reactant5-Cyanothiophene-2-carboxamideHCID 22009814—
Product4-Chloromethyl-2-(5-cyano-2-thienyl)oxazoleHCID 2200965922%

Reaction Steps

In substantially the same manner as in Reference Example 47, 5-cyano-2-thiophenecarboxamide was reacted with 1,3-dichloroacetone to obtain 4-chloromethyl-2-(5-cyano-2-thienyl)oxazole. The yield was 22%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 146-147° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-24fec3037f8f47a7810991f9bbb98d4c
Source noteuspto-grants-2001_04