Aluminium lithium hydride → HCID 22009730, compound

HRID 322331Notes

Reaction equation

HRID 322331 reaction equation
[C:1]1([C:7]2[CH:16]=[C:15]3[C:10]([CH:11]=[C:12]([C:17]([O-])=[O:18])[CH:13]=[N:14]3)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[C:1]1([C:7]2[CH:16]=[C:15]3[C:10]([CH:11]=[C:12]([CH2:17][OH:18])[CH:13]=[N:14]3)=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22009696HCID 22009696, compound

Product 1

HCID 22009730HCID 22009730, compoundYield 39%

Procedure

In substantially the same manner as in Reference Example 72, 7-phenyl-3-quinolinecarboxylate was subjected to reduction with lithium aluminum hydride to obtain 7-phenyl-3-quinolylmethanol. The yield was 39%. Recrystallization from ethyl acetate-hexane gave colorless prisms, 128-129° C.

Sources & evidence

ORD record
ord-6aae75b7658e4031a0483501767a1852
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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