Methanesulfonyl chloride → 3-(3-Chloro-4-methoxymethoxyphenyl)propyl methanesulfonate

HRID 322338Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:12][CH2:13][CH2:14][OH:15])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][O:10][CH3:11].[CH3:16][S:17](Cl)(=[O:19])=[O:18]>>[CH3:16][S:17]([O:15][CH2:14][CH2:13][CH2:12][C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][O:10][CH3:11])=[C:2]([Cl:1])[CH:3]=1)(=[O:19])=[O:18]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 220096143-(3-Chloro-4-methoxymethoxyphenyl)propanol

Product 1

HCID 220095913-(3-Chloro-4-methoxymethoxyphenyl)propyl methanesulfonate

Procedure

In substantially the same manner as in Reference Example 85, 3-(3-chloro-4-methoxymethoxyphenyl)propanol was reacted with methanesulfonyl chloride to obtain 3-(3-chloro-4-methoxymethoxyphenyl)propyl methanesulfonate as an oil. The yield was quantitative.

Sources & evidence

ORD record: ord-58565da7849d48b58894f9d852c8a9c9
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Reaction notes

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