1H-1,2,4-Triazole → HCID 22009665, compound

HRID 322343Notes

Reaction equation

HRID 322343 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]O)=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:28]1[CH:32]=[N:31][CH:30]=[N:29]1>>[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][N:28]4[CH:32]=[N:31][CH:30]=[N:29]4)=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 22009699HCID 22009699, compound

Product 1

HCID 22009665HCID 22009665, compoundYield 60%

Procedure

In substantially the same manner as in Working Example 1, 5-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]pentanol was allowed to react with 1,2,4-triazole to give 1-[5-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]pentyl]-1,2,4-triazole. The yield was 60%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 103-104° C.

Sources & evidence

ORD record
ord-77af76f7af4f4c66ab00d0b56de30739
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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