1H-1,2,4-Triazole → HCID 22009865, compound

HRID 322345Notes

Reaction equation

HRID 322345 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:22][CH2:23][CH2:24]O)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:26]1[CH:30]=[N:29][CH:28]=[N:27]1>>[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:22][CH2:23][CH2:24][N:26]3[CH:30]=[N:29][CH:28]=[N:27]3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 22009678HCID 22009678, compound

Product 1

HCID 22009865HCID 22009865, compoundYield 54%

Procedure

In substantially the same manner as in Working Example 1, 3-[2-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propanol was allowed to react with 1,2,4-triazole to give 1-[3-[2-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole. The yield was 54%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 72-73° C.

Sources & evidence

ORD record
ord-2f8d9ac626474e96acdc655fda904655
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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