1H-1,2,4-Triazole → HCID 22009782, compound

HRID 322346Notes

Reaction equation

HRID 322346 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]O)=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:29]1[CH:33]=[N:32][CH:31]=[N:30]1>>[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][N:29]4[CH:33]=[N:32][CH:31]=[N:30]4)=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 22009681HCID 22009681, compound

Product 1

HCID 22009782HCID 22009782, compoundYield 65%

Procedure

In substantially the same manner as in Working Example 1, 6-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]hexanol was allowed to react with 1,2,4-triazole to give 1-[6-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]hexyl]-1,2,4-triazole. The yield was 65%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 90-91° C.

Sources & evidence

ORD record
ord-db192e8f4a51444aae26c96798505db0
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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