1H-1,2,4-Triazole → HCID 22009676, compound

HRID 322347Notes

Reaction equation

HRID 322347 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23]O)=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:25]1[CH:29]=[N:28][CH:27]=[N:26]1>>[C:1]1(/[CH:7]=[CH:8]/[C:9]2[O:10][CH:11]=[C:12]([CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][N:25]4[CH:29]=[N:28][CH:27]=[N:26]4)=[CH:18][CH:17]=3)[N:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 22009691HCID 22009691, compound

Product 1

HCID 22009676HCID 22009676, compoundYield 75%

Procedure

In substantially the same manner as in Working Example 1, 2-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]ethanol was allowed to react with 1,2,4-triazole to give 1-[2-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]ethyl]-1,2,4-triazole. The yield was 75%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 136-137° C.

Sources & evidence

ORD record
ord-944ab5b3951c42969500fd9292d1ab5b
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

Loading…