Imidazole → HCID 22009842, compound

HRID 322355Notes

Reaction equation

[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.CS(O[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH2:24][C:25]2[N:26]=[C:27](/[CH:30]=[CH:31]/[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[O:28][CH:29]=2)=[CH:19][CH:18]=1)(=O)=O>>[N:1]1([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][C:25]3[N:26]=[C:27](/[CH:30]=[CH:31]/[C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[O:28][CH:29]=3)=[CH:19][CH:18]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

Reactant 2

HCID 795Imidazole

HCID 22009638HCID 22009638, compound

Product 1

HCID 22009842HCID 22009842, compoundYield 66%

Procedure

In substantially the same manner as in Working Example 8, imidazole was allowed to react with 6-[4-[2-[(E) -2-phenylethenyl]-4-oxazolylmethoxy]phenyl]hexyl methanesulfonate to give 4-[4-[6-(1-imidazolyl)hexyl]phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 66%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 108-109° C.

Sources & evidence

ORD record: ord-b204d3d6fd5b41618b36b5b1fc2e0611
Source dataset: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06211215B1

Reaction notes

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