Imidazole → HCID 86756576, compound

HRID 322361Notes

Reaction equation

HRID 322361 reaction equation
Cl[CH2:2][C:3]1[CH:23]=[CH:22][C:6]([O:7][CH2:8][C:9]2[N:10]=[C:11](/[CH:14]=[CH:15]/[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[O:12][CH:13]=2)=[CH:5][CH:4]=1.[NH:24]1[CH:28]=[CH:27][N:26]=[CH:25]1>>[NH:24]1[CH:28]=[CH:27][N:26]=[C:25]1[CH2:2][C:3]1[CH:23]=[CH:22][C:6]([O:7][CH2:8][C:9]2[N:10]=[C:11](/[CH:14]=[CH:15]/[C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[O:12][CH:13]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 22009803HCID 22009803, compound

Product 1

HCID 86756576HCID 86756576, compound

Procedure

In substantially the same manner as in Working Example 25, 4-(4-chloromethylphenoxymethyl)-2-[(E)-2-phenylethenyl]oxazole was allowed to react with imidazole to give 4-[4-(1-imidazolylmethyl)phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 149-150° C.

Sources & evidence

ORD record
ord-13dbcf1769474302aeebe11361ff5edc
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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