ethyl 1H-imidazole-2-carboxylate → ethyl 1-[3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-2-imidazolecarboxylate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	ethyl 1H-imidazole-2-carboxylate	HCID 549404	—
Edukt	3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate	HCID 15521674	—
Produkt	ethyl 1-[3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-2-imidazolecarboxylate	HCID 22009644	68%

Reaktionsschritte

In substantially the same manner as in Working Example 25, 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate was allowed to react with ethyl 2-imidazolecarboxylate to give ethyl 1-[3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-2-imidazolecarboxylate. The yield was 68%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 123-124° C.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US06211215B1
Quelldatensatz	uspto-grants-2001_04
ORD ID	ord-61f115661be048ef9d5f1128e2362ab5
Quellennotiz	uspto-grants-2001_04