Glycarbylamide → HCID 22009731, compound

HRID 322366Notes

Reaction equation

HRID 322366 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]2[N:18]=[C:19](/[CH:22]=[CH:23]/[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[O:20][CH:21]=2)=[CH:11][CH:10]=1)(=O)=O.[NH:30]1[C:34]([C:35]([NH2:37])=[O:36])=[C:33]([C:38]([NH2:40])=[O:39])[N:32]=[CH:31]1>>[C:24]1(/[CH:23]=[CH:22]/[C:19]2[O:20][CH:21]=[C:17]([CH2:16][O:15][C:12]3[CH:11]=[CH:10][C:9]([CH2:8][CH2:7][CH2:6][N:30]4[C:34]([C:35]([NH2:37])=[O:36])=[C:33]([C:38]([NH2:40])=[O:39])[N:32]=[CH:31]4)=[CH:14][CH:13]=3)[N:18]=2)[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 65745GlycarbylamideHCID 155216743-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate

Product 1

HCID 22009731HCID 22009731, compoundYield 44%

Procedure

In substantially the same manner as in Working Example 25, 3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl methanesulfonate was allowed to react with 4,5-imidazoledicarboxamide to give 1-[3-[4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-4,5-imidazoledicarboxamide. The yield was 44%. Recrystallization from ethyl acetate gave colorless prisms, mp 194-195° C.

Sources & evidence

ORD record
ord-d7cf9aeac0a04ce19d4ec63e359c3ec8
Source dataset
uspto-grants-2001_04
Patent number
US06211215B1

Reaction notes

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