HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Chloromethyl)-5-methyl-2-(naphthalen-2-yl)-1,3-oxazole → 1-[4-[4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]butyl]-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Chloromethyl)-5-methyl-2-(naphthalen-2-yl)-1,3-oxazole | HCID 12158073 | — |
| Reactant | 1-[4-(4-Hydroxyphenyl)butyl]-1,2,4-triazole | HCID 22009630 | — |
| Product | 1-[4-[4-[5-Methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]butyl]-1,2,4-triazole | HCID 22009747 | 54% |
Reaction Steps
In substantially the same manner as in Working Example 37, 1-[4-(4-hydroxyphenyl)butyl]-1,2,4-triazole was allowed to react with 4-chloromethyl-5-methyl-2-(2-naphthyl)oxazole to give 1-[4-[4-[5-methyl-2-(2-naphthyl)-4-oxazolylmethoxy]phenyl]butyl]-1,2,4-triazole. The yield was 54%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 134-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-1b4b21077f034bfb802e0abcea841ade |
| Source note | uspto-grants-2001_04 |