1-[4-(4-Hydroxyphenyl)butyl]-1,2,4-triazole → 1-[4-[4-[2-(2-Benzo[b]thienyl)-5-methyl-4-oxazolylmethoxy]phenyl]butyl]-1,2,4-triazole

Participants

Reaction Steps

In substantially the same manner as in Working Example 37, 1-[4-(4-hydroxyphenyl)butyl]-1,2,4-triazole was allowed to react with 2-(2-benzo[b]thienyl)-4-chloromethyl-5-methyloxazole to give 1-[4-[4-[2-(2-benzo[b]thienyl)-5-methyl-4-oxazolylmethoxy]phenyl]butyl]-1,2,4-triazole. The yield was 59%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 131-132° C.

Provenance & Evidence