HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[3-(4-Hydroxy-3-methoxyphenyl)propyl]-1,2,4-triazole → 1-[3-[3-methoxy-4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[3-(4-Hydroxy-3-methoxyphenyl)propyl]-1,2,4-triazole | HCID 22009715 | — |
| Reactant | 4-Chloromethyl-2-styryl-oxazole | HCID 22009752 | — |
| Product | 1-[3-[3-methoxy-4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole | HCID 22009670 | 62% |
Reaction Steps
In substantially the same manner as in Working Example 37, 1-[3-(4-hydroxy-3-methoxyphenyl)propyl]-1,2,4-triazole was allowed to react with 4-chloromethyl-2-[(E)-2-phenylethenyl]oxazole to give 1-[3-[3-methoxy-4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-1,2,4-triazole. The yield was 62%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 113-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-f331cd630d6847788e012101965cc8b4 |
| Source note | uspto-grants-2001_04 |