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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322374Generated: October 25, 2026

4-(Chloromethyl)-2-(3,4-dihydronaphthalen-2-yl)oxazole → 2-(3,4-Dihydro-2-naphthyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole

https://huagongshe.com/reaction/322374

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-2-(3,4-dihydronaphthalen-2-yl)oxazoleHCID 22009637—
Reactant1-[3-(4-Hydroxyphenyl)propyl]imidazoleHCID 22009818—
Product2-(3,4-Dihydro-2-naphthyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazoleHCID 2200968442%

Reaction Steps

In substantially the same manner as in Working Example 37, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(3,4-dihydro-2-naphthyl)oxazole to give 2-(3,4-dihydro-2-naphthyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 42%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 99-100° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-a6f22cafd98b4a0a861aa6708593fbca
Source noteuspto-grants-2001_04