HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Benzo[b]thienyl)-4-chloromethyl-5-methyloxazole → 2-(2-Benzo[b]thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-5-methyloxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Benzo[b]thienyl)-4-chloromethyl-5-methyloxazole | HCID 22009649 | — |
| Reactant | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Product | 2-(2-Benzo[b]thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-5-methyloxazole | HCID 22009718 | 38% |
Reaction Steps
In substantially the same manner as in Working Example 37, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 2-(2-benzo[b]thienyl)-4-chloromethyl-5-methyloxazole to give 2-(2-benzo[b]thienyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]-5-methyloxazole. The yield was 38%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 142-143° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-b767b9d5317c41f78241fc6935b21987 |
| Source note | uspto-grants-2001_04 |