HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzyl-4-(chloromethyl)-1,3-oxazole → 2-Benzyl-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzyl-4-(chloromethyl)-1,3-oxazole | HCID 22009602 | — |
| Reactant | 1-[3-(4-Hydroxyphenyl)propyl]imidazole | HCID 22009818 | — |
| Product | 2-Benzyl-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole | HCID 22009613 | 23% |
Reaction Steps
In substantially the same manner as in Working Example 37, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 2-benzyl-4-chloromethyloxazole to give 2-benzyl-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 23%. Recrystallization from ethyl acetate-isopropyl ether gave colorless prisms, mp 61-62° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-fef9605da5ce413dbb333694fa16f7d4 |
| Source note | uspto-grants-2001_04 |