HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(p-Hydroxyphenyl)imidazole → 4-[4-(1-imidazolyl)phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(p-Hydroxyphenyl)imidazole | HCID 82315 | — |
| Reactant | 4-Chloromethyl-2-styryl-oxazole | HCID 22009752 | — |
| Product | 4-[4-(1-imidazolyl)phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole | HCID 22009823 | 68% |
Reaction Steps
In substantially the same manner as in Working Example 37, 1-(4-hydroxyphenyl)imidazole was allowed to react with 4-chloromethyl-2-[(E)-2-phenylethenyl]oxazole to give 4-[4-(1-imidazolyl)phenoxymethyl]-2-[(E)-2-phenylethenyl]oxazole. The yield was 68%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 160-162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06211215B1 |
| Source dataset | uspto-grants-2001_04 |
| ORD ID | ord-a2539587f2ab45ccb443b3bde9bdc63f |
| Source note | uspto-grants-2001_04 |