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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 322379Generated: October 25, 2026

4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-oxazole → 2-(4-Chlorophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole

https://huagongshe.com/reaction/322379

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Chloromethyl)-2-(4-chlorophenyl)-1,3-oxazoleHCID 7131527—
Reactant1-[3-(4-Hydroxyphenyl)propyl]imidazoleHCID 22009818—
Product2-(4-Chlorophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazoleHCID 2200969376%

Reaction Steps

In substantially the same manner as in Working Example 48, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(4-chlorophenyl) oxazole to give 2-(4-chlorophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 76%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 116-117° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06211215B1
Source datasetuspto-grants-2001_04
ORD IDord-3b4ed062b41343f0bee35c0e40e06a62
Source noteuspto-grants-2001_04