4-[4-(Chloromethyl)-1,3-oxazol-2-yl]benzonitrile → 2-(4-Cyanophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole

Beteiligte Stoffe

Reaktionsschritte

In substantially the same manner as in Working Example 48, 1-[3-(4-hydroxyphenyl)propyl]imidazole was allowed to react with 4-chloromethyl-2-(4-cyanophenyl) oxazole to give 2-(4-cyanophenyl)-4-[4-[3-(1-imidazolyl)propyl]phenoxymethyl]oxazole. The yield was 72%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 98-99° C.

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